Synthetic pathways of platinum(IV) 2-phenylpyridine halogenic derivatives as potential anticancer agents

Research Poste

Self-Dual Supergravity from N=2 Strings

A new heterotic N=2 string with manifest target space supersymmetry is constructed by combining a conventional N=2 string in the right-moving sector and a Green-Schwarz-Berkovits type string in the left-moving sector. The corresponding sigma model is then obtained by turning on background fields for the massless excitations. We compute the beta functions and we partially check the OPE's of the superconformal algebra perturbatively in $\alpha'$, all in superspace. The resulting field equations describe N=1 self-dual supergravity.Comment: 32 pages, Latex, discussion in pages 10, 11 revised so that it is compatible with the complex structure chosen in Appendix A. Appendix A slightly expanded. Final versio

Report on CE-19: 16-O(p,n)16-F(0-) in the IUCF Cooler

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors

While many classes of chemotherapeutic agents exist to treat solid tumors, few can generate a lasting response without substantial off-target toxicity despite significant scientific advancements and investments. In this review, the paths of development for nanoparticles, oncolytic viruses, and oncolytic bacteria over the last 20 years of research towards clinical translation and acceptance as novel cancer therapeutics are compared. Novel nanoparticle, oncolytic virus, and oncolytic bacteria therapies all start with a common goal of accomplishing therapeutic drug activity or delivery to a specific site while avoiding off-target effects, with overlapping methodology between all three modalities. Indeed, the degree of overlap is substantial enough that breakthroughs in one therapeutic could have considerable implications on the progression of the other two. Each oncotherapeutic modality has accomplished clinical translation, successfully overcoming the potential pitfalls promising therapeutics face. However, once studies enter clinical trials, the data all but disappears, leaving pre-clinical researchers largely in the dark. Overall, the creativity, flexibility, and innovation of these modalities for solid tumor treatments are greatly encouraging, and usher in a new age of pharmaceutical development

How to Do Things Without Words: Infants, utterance-activity and distributed cognition

Clark and Chalmers (1998) defend the hypothesis of an ‘Extended Mind’, maintaining that beliefs and other paradigmatic mental states can be implemented outside the central nervous system or body. Aspects of the problem of ‘language acquisition’ are considered in the light of the extended mind hypothesis. Rather than ‘language’ as typically understood, the object of study is something called ‘utterance-activity’, a term of art intended to refer to the full range of kinetic and prosodic features of the on-line behaviour of interacting humans. It is argued that utterance activity is plausibly regarded as jointly controlled by the embodied activity of interacting people, and that it contributes to the control of their behaviour. By means of specific examples it is suggested that this complex joint control facilitates easier learning of at least some features of language. This in turn suggests a striking form of the extended mind, in which infants’ cognitive powers are augmented by those of the people with whom they interact

The first gigayear of bulge star formation in Virgo ellipticals: constraints from their globular cluster systems

Data products from the Advanced Camera for Surveys Virgo Cluster Survey are used to understand the bulge star formation history in early-type galaxies at redshifts z > 2. A new technique is developed whereby observed high-redshift age-metallicity relationships are utilized to constrain the typical formation epochs of metal-rich or "bulge" globular clusters. This analysis supports a model where massive Virgo galaxies underwent an extremely intense mode of bulge globular cluster formation at z ~ 3.5 that was followed by an era of significant bulge growth and little globular cluster production. Intermediate-mass galaxies showed a less-intense period of globular cluster formation at z ~ 2.5 that was synchronized with the bulk of bulge star growth. The transition between the massive and intermediate-mass galaxy star formation modes occurs at a galaxy stellar mass of M_stellar ~ 3 x 10^10 M_sun, the mass where many other galaxy properties are observed to change. Dwarf early-type galaxies in Virgo may have experienced no significant period of bulge globular cluster formation, thus the intense star bursts associated with globular cluster formation may be difficult to directly observe at redshifts z < 4. Though the above conclusions are preliminary because they are based upon uncertain relationships between age and metallicity, the technique employed will yield more stringent constraints as high-redshift galaxy observations and theoretical models improve.Comment: Accepted by MNRAS. 9 pages text. 6 figures

Gender essentialism and occupational segregation in insolvency practice

Advances towards egalitarianism in professional recruitment may be offset by processes of occupational re-segregation. Drawing on gender theory this paper investigates horizontal segregation in the UK insolvency profession, as revealed through the lived experiences of female and male practitioners. It is shown that horizontal segregation pervades at different levels of practice and is undergirded by various elements of gender essentialism. Physical essentialism explains why insolvency practice has been traditionally gendered male. Interactional essentialism combines with the management of work-life balance to define the subfields of corporate and personal insolvency as masculine and feminine respectively. Gender essentialist assumptions also pervade the distribution of roles and the allocation of work tasks. Networks are identified as arenas for the reproduction and perpetuation of occupational segregation. The findings indicate the continuing potency of gender in everyday professional life, the limitations of diversity-orientated policies and the complexities of formulating transformative agendas